Plants are made of many different cell types, yet all of these derive from three major tissue types: epidermis, ground tissue and vascular tissue. Our group is interested in how these tissues are first specified in the early embryo. A second interest is in understanding how the initial specification of tissues in the embryo triggers the potential to grow indeterminately through the establishment of tissue-specific stem cells. We use a combination of genetics, proteomics, transcriptomics, imaging and modeling approaches to understand the mechanistic basis of these processes in the Arabidopsis embryo. I will present our recent findings that reveal a central role for transcriptional networks triggered by the auxin-dependent transcription factor MONOPTEROS.