By: 
Morten Peterson
Host: 
Peter Bozhkov
Location: 
Lecture hall K. Teaching building, Ultuna
Date: 
2022-12-15
Time: 
14:00 - 15:00
Mediators and regulators of temporary and somatic reprogramming in plants

Autophagy has been reported to regulate many different cellular processes. Autophagy has also been implicated in induced pluripotent stem cell formation, cellular regeneration, and stem cell survival in animals. Using the plant models Arabidopsis thaliana and Physcomitrium patens, we recently provided comprehensive evidence that autophagy functions in many types of cellular reprogramming. Autophagy mediates the switch between several somatic cell programs by removing cellular components that are no longer required. Moreover, pluripotent cells of autophagy mutants exhibit de-regulated cell growth and organogenesis, while somatic cells of autophagy deficient plants struggle to dedifferentiate and produce pluripotent cells. In addition, overexpressing ATG8 had a positive effect on cellular reprogramming in wild type plants but not in an autophagy-deficient background. Interestingly, dedifferentiation provoked by wounding also depends upon the activation of a wound activated MAP kinase cascade also responsive to danger associated molecular patterns (DAMPs). These observations indicate that autophagy and DAMP activated regulatory units promotes phenotypic plasticity in plants and functions in wound induced regeneration.